✦ LIBER ✦
Synthetic studies toward cyathin diterpenoids: approach to the tricyclic system through intramolecular Heck-type cyclization
✍ Scribed by Cyrille Thominiaux; Angèle Chiaroni; Didier Desmaële
- Book ID
- 104250989
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 145 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The enantioselective synthesis of a model of the core ring system of cyathin diterpenes is described. The key tricyclic acetate 4 was assembled via an intramolecular Heck-type cyclization of the chiral triflate 8. Acetate 4 was taken through to model cyathan ketones 3a and 3b by a one-carbon ring expansion.