Synthetic studies toward amphidinolide A: Synthesis of fully functionalized subunits
โ Scribed by Lamont R. Terrell; Joseph S. Ward III; Robert E. Maleczka Jr.
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 256 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
A retrosynthetic breakdown of amphidinolide A affords four fragments A-D and illustrates the main synthetic challenges of this molecule. A concise stereoselective synthesis of the four appropriately functionalized subtargets is described.
๐ SIMILAR VOLUMES
Unprecedented synthetic transformations were demonstrated during the preparation of fully functionalized cyclization precursors of type 2, in a synthetic approach to sarcodictyin A and B (la,b) and eleutherobin (le).
A stereocontrolled synthesis of two fragments comprising the macrocyclic core of Phorboxazole A is described. The C3-C19 bis-pyran segment is prepared utilizing reiterative enantioselective allylations from homochiral aUylstannanes followed by stereoselective cyclizations. The pentasubstituted tetra