Synthetic studies related to CP-225,917
β Scribed by Clive, Derrick LJ; Sgarbi, Paulo WM; He, Xiao; Sun, Shaoyi; Zhang, Junhu; Ou, Ligong
- Book ID
- 121863521
- Publisher
- NRC Research Press
- Year
- 2003
- Tongue
- French
- Weight
- 508 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0008-4042
- DOI
- 10.1139/v03-086
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The enolate derived from ester 15 reacts with diketone 10 stereoselectively (10:1 ), and the major isomer can be converted into lactone 21. This rearranges in boiling 1,2dichlorobenzene to afford the tricycfic lactone 22, a model compound which shares with CP-225,917 (1) the bridgehead double bond,