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Synthetic Studies on the Nhatrangins: Stereoselective Access to an Advanced Aldehyde Intermediate

✍ Scribed by Raffier, Ludovic; Piva, Olivier


Book ID
118268568
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
671 KB
Volume
2013
Category
Article
ISSN
1434-193X

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An efficient and stereoselective approach to the synthesis of coenzyme Q 10 is described (Scheme). The MeOCH 2 -protected p-hydroquinone 4 containing the C 5 (E)-allyl (tert-butyl)dimethylsilyl ether moiety was obtained via a halogen -lithium exchange of the MeOCH 2 -proctected 2-bromo-5,6dimethoxy-