Synthetic Studies on Sialoglycoconjugates 41: A Facile Total Synthesis of Ganglioside GM 2
โ Scribed by Hasegawa, Akira; Nagahama, Takao; Ohki, Hitoshi; Kiso, Makoto
- Book ID
- 120349283
- Publisher
- Taylor and Francis Group
- Year
- 1992
- Tongue
- English
- Weight
- 858 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0732-8303
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Recently, as more and more biological functions2-9 of gangliosides are being revealed, their stereocontrolled synthesis is urgently required to aid the elucidation of their functions at the molecular level. In particular, a facile systematic synthesis of polysialogangliosides containing the cu-sialy
Mammals, birds, amphibians, and teleost fish all have similar brain gangliosides. These gangliosides are of the ganglio-series with predominantly, gangliotetraose, P-o-Gal-(1 + 3)-fl-D-GalNAc-(1 + +&o-Gal-( 1+ 4)-~-Gk, as the neutral oligosaccharide, though with a varying degree of sialylation. Sinc
Gangliosides, sialic acid containing glycosphingolipids, are a class of structurally diverse molecules commonly present in vertebrate plasma membranes and especially enriched in nerve tissues\*. These membrane components are thought to be responsible for important physiological activities, and it is