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Synthetic studies on ecteinascidin 743: asymmetric synthesis of the versatile amino acid component

✍ Scribed by Wei Jin; Robert M Williams

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 198 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)01082-7

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✦ Synopsis

The asymmetric synthesis of the modified tyrosine derivative as a basic building block for the ecteinascidin and safracin family of antitumor alkaloids has been achieved in nine steps and 39% overall yield.

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