Synthetic Studies on 3-Arylquinazolin-4-ones: Intramolecular Nucleophilic Aromatic Substitution Reaction of 2-Carboxamido-3-arylquinazolin-4-ones and Its Application to the Synthesis of Secondary Aryl Amines.
β Scribed by Haruhiko Fuwa; Toshitake Kobayashi; Takashi Tokitoh; Yukiko Torii; Hideaki Natsugari
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 32 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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The reaction of 3-substituted-4-hydroxyroxy-2H-1,2-be~othiazine 1,l-dioxides with aryl isocyanate under different equivalents of strong base NaH was studied. Seventeen of new derivatives were obtained whose structures were characterized by ' H NMR, IR, MS, elementary analysis and FeCls test. ## Key
## Abstract magnified image Described herein is the development of a palladium(II)βcatalyzed twoβ or threeβcomponent reaction of 2β(1βalkynyl)β2βalkenβ1βones with nucleophiles and allylic chlorides. Various types of nucleophiles such as __Oβ__, __Nβ__, __C__βbased nucleophiles and olefinβtethered