Synthetic studies of zoanthamine/norzoanthamine alkaloids: Construction of the heterocyclic aminal core (CDEFG ring)
โ Scribed by Naotsuka Hikage; Hironori Furukawa; Ken-ichi Takao; Susumu Kobayashi
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 200 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
Stereocontrolled construction of the fully functionalized heterocyclic aminal core (CDEFG ring) of the zoanthamine and norzoanthamine family was successfully accomplished from the monocyclic ketoacid which was prepared from ( + )-Wieland-Miescher ketone and D-glutamic acid.
๐ SIMILAR VOLUMES
A concise enantiocontrolled synthesis of the enamine-aminal heterocyclic core found in the zoantharnine alkaloids is presented. Conjugate addition of a chiral imine provides for excellent diastereofacial selectivity in the generation of the quaterna~. Cgasymmetry of 4.