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Synthetic studies of the antitumor antibiotic streptonigrin. I. Synthesis of the A-B ring portion of streptonigrin

✍ Scribed by T. K. Liao; Wayne H. Nyberg; C. C. Cheng


Book ID
112123873
Publisher
Journal of Heterocyclic Chemistry
Year
1976
Tongue
English
Weight
200 KB
Volume
13
Category
Article
ISSN
0022-152X

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Synthesis of ABC Analogues of the Antitu
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AbstractÐABC analogues of the antitumour antibiotic streptonigrin, that contain the key metal chelation site and redox-active quinone unit that are essential for biological activity, were prepared via palladium catalysed cross-coupling of 2-iodo-8-nitroquinoline or 2-iodo-6methoxy-5-nitroquinoline w