Synthetic studies of polyene macrolides, synthesis of a C29–37 fragment for amphotericin B and nystatin
✍ Scribed by Dee W Brooks; Rosemary P Kellogg
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 262 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Structural units corresponding to the Clc-C2a and C32-C3B segments of amphotericin B were synthesized from a single chiral progenitor. In the previous paper,' we described an efficient and convergent synthesis of the Cl-Cl3 segment of amphotericin B2 starting with (S)-4-hydroxymethyl butyrolactone w
An efficient stereoselective synthesis of C4-12 fragment of the cembranoids, sarcophytonolides E-G and L and C5-11 fragment of sarcophytonolide L is described. The C4-12 building block is efficiently assembled starting from chiral pool material (R)-carvone employing the Baeyer-Villiger oxidation, mo