Synthetic studies of erythromycin derivatives: 6-O-methylation of (9S)-12,21-anhydro-9-dihydroerythromycin A derivatives
β Scribed by Wei-Min Chen; Henry N.C Wong; Daniel T.W Chu; Xiaodong Lin
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- French
- Weight
- 483 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0040-4020
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## Abstract __X__βray structure analysis of the title compound (II) is reported. Diffractometer data and the FaltmolekΓΌl method were used. Refinement converged at R 0.044. The molecule assumes the __syn,syn__βconformation in the crystal.
A study aimed at developing an enantioselective synthesis of the title compound 23, a 2-monodeoxy analogue of the naturally occurring ()-2-keto-3-deoxy-d-glycero-d-galacto-2-nononic acid (KDN), is reported. From d-mannose as starting material, the chiral 1,3-diene 10, activated by a silyloxy substit