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Synthetic studies of a constrained ring didemnin analog

✍ Scribed by Scott C. Mayor; Amy J. Pfizenmayer; Richard Cordova; Wen-Ren Li; Madeleine M. Joullié

Book ID
103976956
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
244 KB
Volume
5
Category
Article
ISSN
0957-4166

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✦ Synopsis

An asymmetric DiebAlder rexlion in the prexnce of 3.0 M lihium pexcthmeddhyl e&x WILS used IO Bencrate the initial sbxwcbnisby for a c@hexaoc amino acid (3). a key iatexmediate in the pepantioa of a fused ring didemnin Malog. This CMlstrained ring macrocycle should pvidc insight into the binding sibe conformation of the biive species.

📜 SIMILAR VOLUMES

Synthetic studies of didemnins. IV. Synt
Synthetic studies of didemnins. IV. Synthesis of the macrocycle
✍ William R. Ewing; Bruce D. Harris; Wen-Ren Li; Madeleine M. Joullie 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 273 KB

A stereocontrolled route to the 23-membered macrocycle found in the didemnins is described. As a continuation of our synthetic studies of the didemnins,z we now wish to report our synthesis of the didemnins' macrocycle. The didemnins (1) are a new class of depsipeptides originally isolated from a C