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Synthetic strategies of nonpeptidic β-secretase (BACE1) inhibitors

✍ Scribed by Giuseppe La Regina; Francesco Piscitelli; Romano Silvestri

Publisher
Journal of Heterocyclic Chemistry
Year
2009
Tongue
English
Weight
194 KB
Volume
46
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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J. Heterocyclic Chem., 46, 10 (2009).

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✍ Romano Silvestri 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 623 KB

## Abstract β‐Amyloid cleaving enzyme‐1 (BACE1) has become a significant target for the therapy of Alzheimer's disease. After the discovery of the first non‐peptidomimetic β‐secretase inhibitors by Takeda Chemicals in 2001, several research teams focused on SAR development of these agents. The non‐