Synthetic retinoids inhibit histamine release from isolated human mast cells

✍ Scribed by D. Eichelberg; W. Schmutzler

• Publisher: Springer-Verlag
• Year: 1988
• Tongue: English
• Weight: 274 KB
• Volume: 280
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00456846

✦ Synopsis

In view of the immunomodulating properties of the synthetic retinoids etretinate and isotretinoin, their effects on isolated human mast cells were investigated. At concentrations of 10 -6 to 10-SM, isotretinoin and at 10-6 M to 5 x 10-s M, etretinate inhibited concanavalin-A induced histamine release dosedependently. Effective concentrations corresponded to achievable levels under therapeutic conditions in man. Without any additional stimulant, both drugs exhibited no appreciable effects with the exception of a toxic damage at very high levels.