---------------------Note: This study is meant for inspiration for scientific circles around the world with respect to scientific inquiry. The hypothesis, results, data and so forth of this study shall not be subjected to any interpretation, truncation or obfuscation in order to serve the purposes of certain groups of interest. The authors that contributed to this study are granted full copyright to the results, innovations and data used hereof.
This is part of a series of studies published in order to better understand the global issue of the SARS-CoV-2 pandemic. The origins of the virus are yet unknown.
-COVID-19 is just an umbrella term for what has been named as 2019-nCov, meaning novel coronavirus disease that originated in 2019, and has been classified further as SARS-CoV-2.
Any misuse of this term is strictly forbidden as it creates confusion and misinterpretation, misunderstanding of the roots and original structure of the virus.
The intent of the authors should not be subjected to any misrepresentation either.
Unacreditted interpretation of this study is strictly forbidden under international law.------------------------
The spike (S) protein of severe acute respiratory syndrome
coronavirus (SARS-CoV) is an important viral structural
protein. Based on bioinformatics analysis, 10 antigenic peptides
derived from the S protein sequence were selected and synthesized.
The antigenicity and immunoreactivity of all the peptides
were tested in vivo and in vitro. Four peptides (P6, P8, P9 and
P10) which contain B cell epitopes of the S protein were identified,
and P8 peptide was confirmed in vivo to have a potential in
serological diagnosis. By using a syncytia formation model, we
tested the neutralization ability of all 10 peptides and their corresponding
antibodies. It is interesting to find that P8 and P9
peptides inhibited syncytia formation, suggesting that the P8
and P9 spanning regions may provide a good target for anti-
SARS-CoV drug design. Our data suggest that we have identified
peptides derived from the S protein of SARS-CoV, which
are useful for SARS treatment and diagnosis.