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Synthetic Models Related to Furanocoumarin-CYP 3A4 Interactions. Synthesis of Furanocoumarin Derivatives as Potent Inhibitors of CYP 3A4.

โœ Scribed by Kazuaki Oda; Yukio Tamai; Yuki Yamaguchi; Teruki Yoshimura; Keiji Wada; Minoru Machida; Naozumi Nishizono


Publisher
John Wiley and Sons
Year
2007
Weight
17 KB
Volume
38
Category
Article
ISSN
0931-7597

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Assessment of ifosfamide pharmacokinetic
โœ Rashmi Chugh; Thomas Wagner; Kent A. Griffith; Jeremy M.G. Taylor; Dafydd G. Tho ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 190 KB

## Abstract ## BACKGROUND. Ifosfamide is a chemotherapeutic agent that requires cytochrome P450 3A (CYP3A) for bioactivation and metabolism. To the authors' knowledge, the correlation between dose, pharmacokinetics, CYP3A, and toxicity has not been fully evaluated. A randomized Phase II trial was