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Synthetic microbial chemistry, XXIII. Synthesis of optically active virginiae butanolides A, B, C, and D and other autoregulators from streptomycetes

✍ Scribed by Mori, Kenji ;Chiba, Naoki


Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
746 KB
Volume
1990
Category
Article
ISSN
0947-3440

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✦ Synopsis


Abstract

Optically active A‐factor (1), the factor from Streptomyces viridochromogenes (2), the factors from S. bikiniensis and S. cyaneofuscatus (3–5), and virginiae butanolides A (6), B (7), C (8), and D (9) were synthesized starting from (S)‐(−)‐paraconic acid (10). The absolute configurations of virginiae butanolides A and C were deduced to be (2__S__,3__R__,1′R).