In order to search for novel herbicides with high activity and selectivity, a series of thio(seleno) phosphate-phosphonate derivatives were synthesized in good yields by a one-pot procedure using tris(diethylamino)phosphine activated by iodine as the phosphorylating reagent. The structures of all co
Synthetic Methods for Azaheterocyclic Phosphonates and Their Biological Activity
โ Scribed by Kristof Moonen; Inge Laureyn; Christian V. Stevens
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 8 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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โฆ Synopsis
Abstract
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Synthesis of Novel Thio(seleno) Phosphate-phosphonates and Their Biological Activities. -The phosphonates (III), (VI) and (VIII) are prepared by a one-pot procedure using the activated phosphorylating reagent (II) under mild conditions. Some of the products possess potent and selective herbicidal a
Three putative metalloprotease inhibitors were synthesized and tested for their ability to inhibit the catalytic activity of botulinum neurotoxin B light chain (BoNT/B LC). The compounds were designed to emulate the naturally occurring metalloprotease inhibitor phosphoramidon, which has been reporte