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Synthetic metalloproteinase inhibitors block the processing of Pro-TNFα in vitro and in vivo

✍ Scribed by AJH Gearing; K Miller; N Allanson; P Beckert; M Churchill; J Clements; M Crimmin; AH Davidson; AH Drummond; WA Galloway; P Nayee; K Owen; S Patel; W Thomas; G Wells; LM Wood; K Woolley; JL Gordon


Book ID
116172743
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
113 KB
Volume
6
Category
Article
ISSN
1043-4666

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## Abstract Apoptosis of matrix producing cells is common among many inflammatory diseases. The goal of the present study was to examine the apoptotic effects of tumor necrosis factor‐α (TNF‐α) on fibroblastic cells in vivo and to investigate the role of different caspases in this process. This was