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Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

✍ Scribed by Mendes-Pereira, Ana M. (author);Martin, Sarah A. (author);Brough, Rachel (author);McCarthy, Afshan (author);Taylor, Jessica R. (author);Kim, Jung Sik (author);Waldman, Todd (author);Lord, Christopher J. (author);Ashworth, Alan (author)

Book ID: 102833659
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 657 KB
Volume: 1
Category: Article
ISSN: 1757-4676
DOI: 10.1002/emmm.200900041

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Synthetic lethal targeting of PTEN mutan

Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

✍ Mendes-Pereira, Ana M. (author);Martin, Sarah A. (author);Brough, Rachel (author 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 657 KB

The tumour suppressor gene, phosphatase and tensin homolog (PTEN), is one of the most commonly mutated genes in human cancers. Recent evidence suggests that PTEN is important for the maintenance of genome stability. Here, we show that PTEN deficiency causes a homologous recombination (HR) defect in