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Synthetic Inhibitors of HIV-1 Protease Block Processing of Pr55gag and Pr160gag-po1 Polyproteins in Infected T Lymphocytes

✍ Scribed by D. M. LAMBERT; T. D. MEEK; G. B. DREYER; T. K. HART; T. J. MATTHEWS; J. J. LEARY; P. J. BUGELSKI; B. W. METCALF; S. R. PETTEWAY JR.


Book ID
119864161
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
508 KB
Volume
616
Category
Article
ISSN
0890-6564

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In this work the proteolytic activity in the supernatant and inside insect cells in culture was evaluated for different multiplicities of infection (MOI) and times of infection (TOI). Several methods to detect proteolytic activity in insect cells were tested and that using fluorescein thiocyanite-ca