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Synthetic Gene Network: Modeling, Analysis and Robust Design Methods

✍ Scribed by Bor-Sen Chen; Yu-Chao Wang


Publisher
CRC Press/Taylor & Francis Group
Year
2014
Tongue
English
Leaves
216
Category
Library

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✦ Synopsis


This book develops a rational design and systematic approach to construct a gene network with desired behaviors. In order to achieve this goal, the registry of standard biological parts and experimental techniques are introduced at first. Then these biological components are characterized by a standard modeling method and collected in the component libraries, which can be efficiently reused in engineering synthetic Read more...

✦ Table of Contents



Content: Mathematical models and design specifications in synthetic gene networks --
Robust synthetic biology designs based on system dynamic models --
Robust synthetic biology designs based on network evolutionary methods --
Construction of promoter and promoter-RBS libraries for synthesis of gene networks --
Robust synthetic gene network designs based on library-search method --
Robust design of synthetic biological filter and transistor based on promoter-RBS libraries --
Communication and synchronization of a population of coupled synthetic gene networks.
Abstract: This book develops a rational design and systematic approach to construct a gene network with desired behaviors. In order to achieve this goal, the registry of standard biological parts and experimental techniques are introduced at first. Then these biological components are characterized by a standard modeling method and collected in the component libraries, which can be efficiently reused in engineering synthetic gene networks. Based on the system theory, some design specifications are provided to engineer the synthetic gene networks to robustly track the desired trajectory by employing the component libraries


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