Synthetic entry into cyclopentyl analogs of muscarine
β Scribed by Richard S. Givens; Don R. Rademacher; Janet Kongs; John Dickerson
- Book ID
- 104242986
- Publisher
- Elsevier Science
- Year
- 1974
- Tongue
- French
- Weight
- 168 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
As a result of recent work, it is apparent that desether muscarine (a), the cyclopentyl analog of muscarine (Q, parallels the activity and specificity of muscarine at the cholinergic receptor. 2 This communication reports a stereoselective entry into the substituted cyclopentane system. Ho +.. Earlier we reported a photochemical route 2b CHsn CH+ depicted in Scheme 1 which gave the desired desether muscarine & in an overall yield of 4% from bromoformate z.3 Need for sufficient quantities of $ for resolution and oxidation 2b studies prompt-CH+-+ ed development of a second route.
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