✦ LIBER ✦
Synthetic connections to the aromatic directed metalation reaction. Functionalized aryl boronic acids by ipso borodesilylation. General syntheses of unsymmetrical biphenyls and m-terphenyls
✍ Scribed by M.J. Sharp; W. Cheng; V. Snieckus
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 272 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Aryl boronic acids 2a-d and la-d obtained by metalation-B(OMe)s or metalation silylation-ipso borodesilylation sequences, participate in efficient Pd'-catalyzed cross coupling reactions with aryl bromides to give unsymmetrical biphenyls 3a-d and m_terphenyls 5a-d respectively.
We have recently described1 a general Pd-catalyzed cross coupling protocol2 for the