Synthetic approaches towards indoles on solid phase recent advances and future directions

✍ Scribed by Jan Tois; Robert Franzén; Ari Koskinen

• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 707 KB
• Volume: 59
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(03)00851-2

✦ Synopsis

Introduction 5395 2. Preparation of the indole core on solid phase 5396 2.1. Fischer cyclisation on solid phase 5396 2.2. Palladium-catalysed cyclisation on solid phase 5396 2.3. Madelung cyclisation and intramolecular Wittig reaction in synthesis of indoles 5397 2.4. Solid-phase Nenitzescu indole synthesis 5398 2.5. Other intramolecular cyclizations giving the indole or structurally closely-related core 5398 3. Modification of substituents on the indole ring 5399 3.1. Palladium-catalysed modifications of the indole ring on solid phase 5399 3.2. Modifications leading to tertiary amines 5400 3.3. Modification leading to amides 5400 3.4. Direct functionalisation of the indole ring 5400 3.5. Modification of indoles by substitution at nitrogen 5400 3.6. Modification of the 2-position by Pictet -Spengler reaction 5401 3.7. Indole 3-position modifications 5401 3.8. Functionalisations to other positions 5402 4. Conclusions 5402