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Synthetic approaches to peptide analogues containing 4, 4-difluoro-L-proline and 4-keto-L-proline

✍ Scribed by SUFRIN, JANICE R. ;BALASUBRAMANIAN, TRICHEY M. ;VORA, CHANDRANAN M. ;MARSHALL, GARLAND R.


Book ID
115097944
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
329 KB
Volume
20
Category
Article
ISSN
0367-8377

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A rapid approach has been developed to provide a novel series of 4-pyridinyl proline derivatives as potential stereoselective catalysts. Nucleophilic displacement at the 4-pyridinyl position proved straightforward using proline but required microwave heating to proceed when using the more bulky a-me