✦ LIBER ✦
Synthetic approaches to new anthracyclines: 4,11-dideoxy-2-hydroxy-β-rhodomycinone and its glycosides
✍ Scribed by Hiroshi Tanaka; Takeo Yoshioka; Yasutaka Shimauchi; Akihiro Yoshimoto; Tomoyuki Ishikura; Hiroshi Naganawa; Tomio Takeuchi; Hamao Umezawa
- Book ID
- 104233750
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- French
- Weight
- 215 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
f)-Z-Acetoxy-4,ll-dideoxy-lO-oxo-B-rhodomycinone [(+)-621 was synthesized from the tricyclic quinone ((l_) by a short efficient route in an overall yield of about 54%. Reaction of (!)-@ with protected daunosamine followed by reduction and deprotection provided the optically active o-glycosidated anthracycline (II) with the 7S,9R,lOR-configuration.
Furthermore, the amino and aromatic hydroxy gro%s Of ,II_ were methylated.