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Synthetic Approaches to Indolo[6,7- a ]pyrrolo[3,4- c ]carbazoles: Potent Cyclin D1/CDK4 Inhibitors

โœ Scribed by Faul, Margaret M.; Engler, Thomas A.; Sullivan, Kevin A.; Grutsch, John L.; Clayton, Marcella T.; Martinelli, Michael J.; Pawlak, Joseph M.; LeTourneau, Michael; Coffey, D. Scott; Pedersen, Steven W.; Kolis, Stanley P.; Furness, Kelly; Malhotra, Sushant; Al-awar, Rima S.; Ray, James E.


Book ID
120434728
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
189 KB
Volume
69
Category
Article
ISSN
0022-3263

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Aryl[a]pyrrolo[3,4-c]carbazoles as selec
โœ Concha Sanchez-Martinez; Chuan Shih; Margaret M. Faul; Guoxin Zhu; Michael Paal; ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 195 KB

The synthesis of new analogues of Arcyriaflavin A in which one indole ring is replaced by an aryl or heteroaryl ring is described. These new series of aryl[a]pyrrolo[3,4-c]carbazoles were evaluated as inhibitors of Cyclin D1-CDK4. A potent and selective D1-CDK4 inhibitor, 7a (D1-CDK4 IC 50 =45 nM),