Synthetic Approaches to Indolo[6,7- a ]pyrrolo[3,4- c ]carbazoles: Potent Cyclin D1/CDK4 Inhibitors
โ Scribed by Faul, Margaret M.; Engler, Thomas A.; Sullivan, Kevin A.; Grutsch, John L.; Clayton, Marcella T.; Martinelli, Michael J.; Pawlak, Joseph M.; LeTourneau, Michael; Coffey, D. Scott; Pedersen, Steven W.; Kolis, Stanley P.; Furness, Kelly; Malhotra, Sushant; Al-awar, Rima S.; Ray, James E.
- Book ID
- 120434728
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 189 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The synthesis of new analogues of Arcyriaflavin A in which one indole ring is replaced by an aryl or heteroaryl ring is described. These new series of aryl[a]pyrrolo[3,4-c]carbazoles were evaluated as inhibitors of Cyclin D1-CDK4. A potent and selective D1-CDK4 inhibitor, 7a (D1-CDK4 IC 50 =45 nM),
## Abstract For Abstract see ChemInform Abstract in Full Text.