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Synthetic approaches to Cinchona alkaloids: the C-8/C-9 disconnection strategy

✍ Scribed by Raphaël Jankowski; Delphine Joseph; Christian Cavé; Françoise Dumas; Michèle Ourevitch; Jacqueline Mahuteau; Georges Morgant; Nada Bosnjaković Pavlović; Jean d'Angelo

Book ID: 104253655
Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 164 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00926-2

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✦ Synopsis

When conducted in DMSO, the Hu ¨nig's base-promoted condensation of 3-quinuclidinone with quinoline-4-carboxaldehyde gave an equimolar mixture of epimeric aldols 8 with an excellent yield.

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