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Synthetic approaches to bridgehead nitrogen methanesulfonamide derivatives of 3-amino-2-thioxo-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-ones, potential cox-2 selective inhibitors

✍ Scribed by Giuseppe Granata; Salvatore Barbagallo; Antonio Perdicaro; Agostino Marrazzo; Andrea Santagati; Laura Lombardo; Venera Cardile

Publisher
Journal of Heterocyclic Chemistry
Year
2006
Tongue
English
Weight
162 KB
Volume
43
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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Methane sulfonamide derivatives of 3‐amino‐2‐thioxo‐2,3‐dihydrothieno[2,3‐d]pyimidin‐4(1__H__)‐one, potential selective COX‐2 inhibitors, were synthesized and their structural elucidation is here reported. Some derivatives, at 10 μM concentration, showed a significant percentage of inhibition in some in vitro experiments.

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✍ Mykhaylo V. Vovk; Volodymyr A. Sukach; Volodymyr V. Pyrozhenko; Andriy V. Bol'bu 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 22 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

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## Abstract Bridgehead nitrogen heterocycles **3a**, **b** and **6a**, **b** containing the thieno‐pyrimidine system have been prepared from the versatile intermediates 3‐amino‐2,3‐dihydro‐5,6‐dimethyl‐2‐thioxo‐thieno[2,3‐__d__]pyrimidin‐4‐(1__H__)‐one **1** and its hydrazinium or potassium salts *