๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Synthetic approaches to 5,7-disubstituted imidazo[5,1-f][1,2,4]triazin-4-amines

โœ Scribed by Douglas S. Werner; Hanqing Dong; Mridula Kadalbajoo; Radoslaw S. Laufer; Paula A. Tavares-Greco; Brian R. Volk; Mark J. Mulvihill; Andrew P. Crew

Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
391 KB
Volume
51
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

โœฆ Synopsis

The preparation of 5,7-disubstituted imidazo [5,1-f ][1,2,4]triazin-4-amines, exemplified by 5-[3-(benzyloxy)phenyl]-7-cyclobutylimidazo[5,1-f ][1,2,4]triazin-4-amine, was developed through a linear and three convergent synthetic strategies, with the latter providing the greatest flexibility for diversification at the 5-position at the last step of the synthesis.

๐Ÿ“œ SIMILAR VOLUMES

5,5-Dimethyl-2-phenyl-4,5-dihydro-1,2,4-
5,5-Dimethyl-2-phenyl-4,5-dihydro-1,2,4-triazolo[1,5-a][1,3,5]triazin-7-amine
โœ Dolzhenko, Anton V. ;Tan, Geok Kheng ;Koh, Lip Lin ;Dolzhenko, Anna V. ;Chui, Wa ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› International Union of Crystallography ๐ŸŒ English โš– 945 KB

The title compound, C 12 H 14 N 6 , was synthesized via cyclocondensation of 5-amino-1-guanyl-3-phenyl-1,2,4-triazole with acetone. Only one tautomeric form with an H atom at the triazine N atom was observed in the crystal structure. The compound crystallizes with two almost identical molecules in t

7,7-Dimethyl-2-phenyl-6,7-dihydro-1,2,4-
7,7-Dimethyl-2-phenyl-6,7-dihydro-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amine
โœ Dolzhenko, Anton V. ;Tan, Geok Kheng ;Koh, Lip Lin ;Dolzhenko, Anna V. ;Chui, Wa ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› International Union of Crystallography ๐ŸŒ English โš– 494 KB

The title compound, C 12 H 14 N 6 , was synthesized via cyclocondensation of 5-guanidino-3-phenyl-1,2,4-triazole with acetone. Only one tautomeric form with the NH H atom vicinal to the methyl groups was observed in the crystal structure. The triazine ring adopts a flattened half-boat conformation.