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Synthetic approaches to 3-substituted-5′-(N-pyridiniummethyl)-4′,5′-dihydropsoralen

✍ Scribed by Ivan Jabin; Ned D. Heindel; Robert D. Rapp; Jeffrey D. Laskin

Book ID
102893966
Publisher
Journal of Heterocyclic Chemistry
Year
2000
Tongue
English
Weight
732 KB
Volume
37
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

New synthetic approaches to 3‐substituted‐5′‐(N‐pyridiniummethyl)‐4′,5′‐dihydropsoralens are described. The novel pathways presented utilize appropriately substituted coumarins and 4′,5′‐dihydropsoralens. The compounds proposed represent potential therapeutic agents for psoralen uv radiation treatment.

📜 SIMILAR VOLUMES

Synthetic approaches to 4,8-dimethyl-5′-
Synthetic approaches to 4,8-dimethyl-5′-(N-pyridiniummethyl)- 4′,5′-dihydropsoralens and 4,8-dimethyl-5′- (N-aminomethyl)- 4′,5′-dihydropsoralens
✍ Marilyn S. Whittemore; Ned D. Heindel; Ivan Jabin; Christophe Guillon; Thomas E. 📂 Article 📅 2001 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 76 KB

## Abstract New synthetic approaches to 4,8‐dimethyl‐5′‐(__N__‐pyridiniummethyl)‐4′,5′‐dihydropsoralens and 4,8‐dimemyl‐5′‐(__N__‐aminomethyl)‐4′,5′‐dihydropsoralens are described. The 5′‐halomethyl‐4′,5′‐dihydro‐psoralen precursors are formed by electrophilic ring closures of 4,8‐dimethyl‐6‐allyl‐