𝔖 Bobbio Scriptorium
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Synthetic approach toward antibiotic tunicamycins — VI total synthesis of tunicamycins

✍ Scribed by Tetsuo Suami; Hiroaki Sasai; Kazuhiro Matsuno; Nobuo Suzuki; Yoshimasa Fukuda; Osamu Sakanaka


Book ID
104233851
Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
236 KB
Volume
25
Category
Article
ISSN
0040-4039

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The first total synthesis of Manamycin A, as its (+)-enantiomer, is reported. The synthetic route feattwes an asymmetric epoxidation (based on Wynberg's chirai phase transfer methodology) for the preparation of the key epoxyquinol nucleus, and a further demonstration of the utility of the Stifle rea