✦ LIBER ✦
Synthetic applications of the tandem aldol condensation-radical cyclization sequence. A new and highly convergent method for the annulation of carbocycles
✍ Scribed by William R. Leonard; Tom Livinghouse
- Book ID
- 104229171
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 181 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
The sequential treatment of a,R-unsaturated ketones with (phenylseleno)alanes or -es followed by representative 6,y-unsaturated aldehydes has been shown to furnish B-(phenylseleno)ketols in high yield. The reductive cyclization of these species in the presence of tri-z-butyltin hydride affords the corresponding condensed carbocycles with high efficiency.