Synthetic Applications of Lawesson’s Reagent in Reactions with CuI Alkoxides
✍ Scribed by Weifeng Shi; Alexander Rothenberger
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 95 KB
- Volume
- 2005
- Category
- Article
- ISSN
- 1434-1948
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## Abstract The mechanism of the reaction under discussion has been established by investigating the products of the reaction between 2,4‐bis(4‐methoxyphenyl)‐1,3,2,4‐dithiadiphosphetane 2,4‐disulfide (Lawesson’s reagent, LR) and __N__‐alkylhydroxamic acids HAs **1**. The primary intermediate is an
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Lawesson's reagent reacts with visnaginone (2a), khillinone (2b), and o-hydroxyacetophenone (5) to give the 1,2-0xaphosphinane derivatives 4a, 4b, and 6, respectively.
The reaction of w-keto amides with Lawesson's reagent (LR: 2,4-bis(4-methoxyphenyl)-l,3,2,4-dithiadiphosphetane 2,4-disulfide) is described. Treatment of 3-keto amides (2-acylacetamides) I with LR gave the corresponding 3-keto thioamides 2, along with 1,2-dithiole-3-thiones 3. Treatment of 4-keto an