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Synthetic applications of 3-(cyanoacetyl)indoles and related compounds

✍ Scribed by Johnny Slätt; Tomasz Janosik; Niklas Wahlström; Jan Bergman

Publisher: Journal of Heterocyclic Chemistry
Year: 2005
Tongue: English
Weight: 73 KB
Volume: 42
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570420122

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✦ Synopsis

Various synthetic applications of 3-(cyanoacetyl)indoles, as well as syntheses of some related indoles, have been investigated. Diethyl 2-(1H-indol-3-yl)-2-oxoethylphosphonate and a methyl derivative thereof have been prepared in one step from indole. Moreover, it was demonstrated that 3-(cyanoacetyl)indoles are useful starting materials for the preparation of for example 3-(1H-indol-3-yl)-3-oxopropanamides, 3-heteroarylindoles or 3-heteroaroylindoles.

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