An indolizidinone motif with strategically placed substitutents was designed and synthesized as a constrained mimic of D-Phe-Pro-Arg. Low nanomolar inhibition of alpha-thrombin validates the design elements in this inhibitor which also exhibits a 20-fold selectivity for thrombin versus trypsin. An X
✦ LIBER ✦
Synthesis, X-ray crystal structure, electrochemical and antibacterial activity of a silver(I) complex with α-bromo-cinnamaldehyde salicylhydrazone
✍ Scribed by Jun An Liu; Qing Li; Ming Ming Wang; Hui Wang; Guo Qing Gan; Yang Qu; Zhi Dong Lin
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 423 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0340-4285
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