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Synthesis, Ultra-Short Acting Hypnotic Activity, and Metabolic Profile of Ethyl 8-Oxo-5,6,7,8-tetrahydro-thiazolo[3,2-a] [1,3]diazepin-3-carboxylate (HIE-124)

✍ Scribed by Adnan A. Kadi; Hassan A. El-Kashef; Alaa A.-M. Abdel-Aziz; Ghada S. Hassan; Justice Tettey; Mary H. Grant; Jochen Lehmann; Hussein I. El-Subbagh


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
726 KB
Volume
341
Category
Article
ISSN
0365-6233

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Two new natural products, N- (2-methyl-3-oxodec-8-enoyl)corresponding acid chloride, in order to acylate Meldrum's acid. Subsequent aminolysis with pyrrolidine, followed by 2-pyrroline (2) and 2-(hept-5-enyl)-3-methyl-4-oxo-6,7,8,8atetrahydro-4H-pyrrolo[2,1-b]-1,3-oxazine (3), have been methylation