Synthesis, thermal stability and mass spectra of 2-trihalomethyl-1,3,5-dithiazin-4-ones and their 2,3-dihydro derivatives
✍ Scribed by M. V. Vovk; I. G. Krainikova; V. I. Dorokhov
- Publisher
- Springer US
- Year
- 1995
- Tongue
- English
- Weight
- 330 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0009-3122
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## Abstract A series of 2,5‐disubstituted 1,3,5‐dithiazine derivatives were synthesized as potential analogues of the potent dopamine uptake inhibitor GBR 12909. The lipophilic character of the 1,3,5‐dithiazine derivatives were experimentally (log __P__) and computationally (clog __P__) determined.
## Abstract magnified image A new method for the synthesis of substituted 5‐(2‐hydroxyethyl)‐2‐phenylimino‐1,3‐thiazolidin‐4‐ones and 5‐(2‐hydroxyethyl)‐2‐phenylamino‐4,5‐dihydro‐1,3‐thiazol‐4‐ones is described, starting from phenylthioureas and 3‐bromotetrahydrofuran‐2‐one. The reaction proceeds