Synthesis, Structure−Activity Relationships, and Drug Resistance of β-d-3‘-Fluoro-2‘,3‘-Unsaturated Nucleosides as Anti-HIV Agents
✍ Scribed by Zhou, Wen; Gumina, Giuseppe; Chong, Youhoon; Wang, Jianing; Schinazi, Raymond F.; Chu, Chung K.
- Book ID
- 115460979
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 400 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0022-2623
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The synthesis of 9-(2,3.dideoxy-2.fluoro-L.glycero.pent-2-eno-furanosyl)adenine and d~ypoxanthine has been accomplished by direct condensation of silylated 6-chloropurine with key intermediates 8, which were prepared starting from 2,3-O-isopropylidene-L-glyceraldehyde. The synthesized nucleosides we
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