✦ LIBER ✦

Synthesis, structure and investigations of tuberculosis inhibition activities of new 4-methyl-1-substituted-1H-1,2,4-triazole-5(4H)-thione

✍ Scribed by Monika Wujec; Agata Siwek; Marta Swatko-Ossor; Liliana Mazur; Zofia Rzaczynska

Publisher: Journal of Heterocyclic Chemistry
Year: 2008
Tongue: English
Weight: 221 KB
Volume: 45
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570450655

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✦ Synopsis

Abstract

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By the reaction aminomethylation, chloromethylation and acylation of 4‐methyl‐4__H__‐1,2,4‐triazole‐3‐thiol, 4‐methyl‐1‐substituted‐1__H__‐1,2,4‐triazole‐5(4__H__)‐thione 1‐8 were obtained. Molecular structure of the obtained compounds was confirmed by an elemental analysis, IR, ^1^H NMR and ^13^C NMR spectra and additionally by X‐ray analysis for 2. Six new compounds 1,2,4‐7 were tested for antibacterial activity against Mycobacterium smegmatis, Mycobacterium phlei and avirulent strain Mycobacterium H~37~Ra.

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