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Synthesis, Structure, and Cytostatic Properties of New Olivacine Derivatives

✍ Scribed by Ryszard Jasztold-Howorko; Alain Croisy; Daniele Carrez; Iwona Jaroszewicz; Anna Nasulewicz; Marzena Pełczyńska; Adam Opolski

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
95 KB
Volume
337
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

Starting from 2‐(6‐methoxy‐1‐methyl‐9__H__‐carbazol‐2‐yl)ethylamine and 6‐methylpicolinic acid, 9‐methoxy‐5‐methyl‐1‐(6‐methylpyridin‐2‐yl)‐6__H__‐pyrido[4, 3‐b]carbazole 10 and its 6‐alkylderivatives 12 – 17 were obtained. The newly obtained compounds showed significant cytostatic activity against cultured L1210 cells and high cytotoxicity towards various human tumor cell lines.

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4-[2-tetrathiafulvalenyl-ethenyl]pyridine (1) has been prepared from a Wittig reaction between formyltetrathiafulvalene and 4-picolyltriphenylphosphonium chloride hydrochloride. Conversion of the pyridine moiety of 1 by reaction with methyl iodide leads to 4-[2-tetrathiafulvalenyl-ethenyl]-1-methylp