Synthesis, structure, and biological activity of novel 4,5-disubstituted thiazolyl urea derivatives

✍ Scribed by Shao Ling; Zhou Xin; Jin Zhong; Fang Jian-xin

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 165 KB
• Volume: 19
• Category: Article
• ISSN: 1042-7163
• DOI: 10.1002/hc.20375

✦ Synopsis

Abstract

Novel 1‐(2,4‐dichlorophenyl)‐3‐[4‐aryl‐5‐(1__H__‐1,2,4‐triazol‐1‐yl)thiazol‐2‐yl] urea derivatives were synthesized by the reaction of 2‐amino‐4‐sustituted phentyl‐5‐(1__H__‐1,2,4‐triazol‐1‐yl) thiazoles with 2,4‐dichloro‐1‐isocyanatobenzene. Structures of the title compounds were confirmed by the elemental analysis, ^1^H NMR, and single crystal X‐ray diffraction analysis. Biological evaluation showed that some of them possess promising antitumor activities. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:2–6, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20375