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Synthesis, structure, and antibacterial evaluation of new N-substituted-3-amino- 5-oxo-4-phenyl-2,5-dihydro-1H-pyrazole-1-carbothioamides

✍ Scribed by Monika Pitucha; Liliana Mazur; Urszula Kosikowska; Anna Pachuta-Stec; Anna Malm; Łukasz Popiołek; Zofia Rza̧czyńska

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
177 KB
Volume
21
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

Novel N‐substituted‐3‐amino‐5‐oxo‐4‐phenyl‐2,5‐dihydro‐1__H__‐pyrazole‐1‐carbothioamide derivatives were synthesized by means of two methods. First is the cyclization reaction of 1‐(cyanophenyl)acetyl‐4‐substituted thiosemicarbazide, and the second one is reaction of cyanophenyl acetic acid hydrazide with isothiocyanate. Structures of new compounds were confirmed by elemental analysis, ^1^H NMR, and X‐ray diffraction analysis. Biological evaluation showed that some of them possess promising antibacterial activities. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:215–221, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20598

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