Synthesis, structural characterization and bioassay screening of dimeric bis[dicarboxylatotetraorganodistannoxanes]

✍ Scribed by Zhen-Kang Wen; Hai-Bin Song; Miao Du; Yu-Ping Zhai; Liang-Fu Tang

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 138 KB
• Volume: 19
• Category: Article
• ISSN: 0268-2605
• DOI: 10.1002/aoc.960

✦ Synopsis

Reaction of bis(pyrazol-1-yl)acetic acid with n-Bu

2 SnO in a 1 : 1 molar ratio gives dimeric bis[dicarboxylatotetraorganodistannoxanes], {[(n-Bu) 2 (Pz 2 CHCO 2 )Sn] 2 O} 2 (Pz = pyrazol-1-yl or 3,5dimethylpyrazol-1-yl), which are characterized by IR and NMR ( 1 H, 13 C and 119 Sn) spectra and elemental analyses. The X-ray crystal structure analyses indicate that {[(n-Bu) 2 (Pz 2 CHCO 2 )Sn] 2 O} 2 is a centrosymmetric dimer with a cyclic Sn 2 O 2 unit, in which each tin atom is situated in a distorted trigonal bipyramidal geometry. In addition, bis(3,5-dimethylpyrazol-1-yl)acetic acid in the solid state forms a dimer through two intermolecular O-H• • •N hydrogen bonds. These organotin derivatives display low fungicide, insecticide and miticide activities, but display certain cytotoxicities for Hela cells in vitro.