Synthesis, Structural Characteristics and Biological Activities of Complexes of ZnII, CdII, HgII, PdII, and PtII with 2-Acetylpyridine 4-Methylthiosemicarbazone
✍ Scribed by Elena Bermejo; Rosa Carballo; Alfonso Castiñeiras; Ricardo Domínguez; Anthony E. Liberta; Cäcilia Maichle-Mössmer; Michelle M. Salberg; Douglas X. West
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 331 KB
- Volume
- 1999
- Category
- Article
- ISSN
- 1434-1948
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✦ Synopsis
Reaction of 2-acetylpyridine 4-methylthiosemicarbazone 199 Hg-NMR spectroscopy when relevant, the ligand is N,N,Stridentate, coordinating to the metal centre through its (H4ML) with halides of zinc(II), cadmium(II), and mercury(II) afforded complexes of the form [M(H4ML)X 2 ] [M = Zn II (1-pyridine and azomethine nitrogen atoms and its thiocarbonyl sulfur atom, as was confirmed by X-ray diffraction studies in 3), Cd II (4-6) or Hg II (7-9); X = Cl, Br, or I]. Reaction of H4ML with K 2 PdCl 4 and K 2 PtCl 4 gave compounds of the form the cases of 4 • 2 DMSO, 5 • 2 DMSO, 6 • 2 DMSO, 7 • 2 DMSO, 10, and 11. In in-vitro assays, only [Zn(H4ML)Cl 2 ] [M(4ML)Cl] [M = Pd II ( 10) or Pt II (11)]. In all the new compounds, which were characterized by elemental and [Zn(H4ML)Br 2 ] showed some sign of antifungal activity against Aspergillus niger or Paecilomyces variotii. analyses, conductance measurements, and electronic, IR and 1 H-and 13 C-NMR spectroscopy, and by or