✦ LIBER ✦
Synthesis, spectroscopy and polymerization of methyl α-([13C,15N]isocyano)propionate; acetic formic anhydride as N-formylating reagent
✍ Scribed by Edward J. Vlietstra; Roeland J. M. Nolte; Jan W. Zwikker; Wiendelt Drenth; Richard H. A. M. Jansen
- Book ID
- 104588425
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 567 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0165-0513
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✦ Synopsis
Abstract
Methyl α‐([^13^C,^15^N]isocyano)propionate was prepared starting from (±)‐[^15^N]alanine. The amino acid was converted into the methyl ester, which was formylated with acetic [^13^C]‐formic anhydride, to afford the methyl ester of N‐[^13^C]formyl[^15^N]alanine. Dehydration of the latter compound gave the isocyanide, which was polymerized with nickel chloride. ^1^H, ^13^C, ^15^N NMR and IR data of the labelled compounds are presented.