Synthesis, Spectroscopic Characterization and Antitumour Activity of Diorganotin(IV) Derivatives of N-Substituted Ortho-Aminobenzoic Acid

✍ Scribed by Abdelkader Meriem; Monique Biesemans; Rudolph Willem; Bernard Mahieu; Dick de Vos; Peter Lelieveld; Marcel Gielen

• Publisher: Wiley (John Wiley & Sons)
• Year: 2010
• Weight: 286 KB
• Volume: 100
• Category: Article
• ISSN: 0037-9646
• DOI: 10.1002/bscb.19911000504

✦ Synopsis

Four compounds of the type [ ( o -R N H -C , H ~C O O ) ( C H ~C H ~C H ~C H ~) ~S ~] ~O and [(o-CH3NH-CgHqCOO)(CH3)2Sn]120 have been prepared, characterized by 'H, 13C, ' 19Sn NMR, and by

Mbssbauer and mass spectrometry. They have been tested in vifro against two human tumour cell lines, nl. MCF-7 (mammary tumour) and WiDr (colon carcinoma), and found to score slightly better than cis-platin but markedly less than other cytostatic agents.

lntroductlon

We recently described the synthesis, characterization and antitumour activity of diorganotinbis(orthoaminobenzoates) and of some of their N-substituted derivatives('). They appeared to be more active in vitro than cis-platin against MCF-7 and gave IDs0 values comparable to those obtained for cis-platin against WiDr. Therefore we decided to prepare some corresponding bis(ortho-aminobenzoatodi-nbutyltin) oxides.

Results and discussion

The compounds prepared are listed in chart 1