✦ LIBER ✦

Synthesis, separation, and stereochemistry of diastereomeric oligodeoxyribonucleotides having a 5′-terminal internucleotide phosphorothioate linkage

✍ Scribed by Wojciech J. Stec; Gerald Zon

Book ID: 104233947
Publisher: Elsevier Science
Year: 1984
Tongue: French
Weight: 269 KB
Volume: 25
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)81582-3

No coin nor oath required. For personal study only.

✦ Synopsis

An automated, solid-phase, phosphoramidite-coupling method provided the title -_compounds, up to a hexadecamer, for HPLC isolation of diastereomerically pure samples, and comparative digestions with snake venom phosphodiesterase and nuclease Pl.

📜 SIMILAR VOLUMES

Studies on stereospecific formation of P

Studies on stereospecific formation of P-chiral internucleotide linkage. Synthesis of (RP,RP)- and (SP,SP)-thymidylyl(3′,5′)thymidylyl(3′,5′)thymidine di(O,O-phosphorothioate) using 2-nitrobenzyl group as a new s-protection

✍ Z.J. Lesnikowski; M.M. Jaworska 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 337 KB

RP,RP)-and (SP,SP)-diastereomers of thymidylyl(3',5')thymidyly1(3',5')thymidine di (O,O-phosphorothioate (6) were prepared in the stereospecific reaction of (RF)-or (SP)-isomer of 5'-0-monomethoxytritylthytnidine 3'U1~14-nitroph~nyl)-S-(X-nitrobenzyl)phosphorothioate] (2) with 5'-0tt activatd 3'Uace