✦ LIBER ✦

Synthesis, selective anti-Helicobacter pylori activity, and cytotoxicity of novel N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides

✍ Scribed by Franco Chimenti; Bruna Bizzarri; Adriana Bolasco; Daniela Secci; Paola Chimenti; Arianna Granese; Simone Carradori; Daniela Rivanera; Alessandra Zicari; M. Maddalena Scaltrito; Francesca Sisto

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 270 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.06.048

No coin nor oath required. For personal study only.

✦ Synopsis

a b s t r a c t N-substituted-3-carboxamido-coumarin derivatives were prepared and evaluated for selective antibacterial activity against 20 isolates of Helicobacter pylori clinical strains, including five metronidazole resistant ones. Some of them possessed the best activity against H. pylori metronidazole resistant strains with MIC values lower than the drug reference (metronidazole). Furthermore, anti-inflammatory activity through the inhibition of the IL-8 production was investigated.

📜 SIMILAR VOLUMES

Synthesis and in vitro Selective anti-He

Synthesis and in vitro Selective anti-Helicobacter pylori Activity of N-Substituted-2-oxo-2H-1-benzopyran-3-carboxamides.

✍ Bruna Bizzarri; et al. et al. 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 12 KB 👁 2 views

A Novel Class of Selective anti-Helicoba

A Novel Class of Selective anti-Helicobacter pylori Agents 2-Oxo-2H-chromene-3-carboxamide Derivatives.

✍ Bruna Bizzarri; et al. et al. 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 23 KB 👁 2 views

ChemInform Abstract: Synthesis and Photo

ChemInform Abstract: Synthesis and Photobiological Activity of N-Substituted 2-Oxo-2H-1- benzopyran-3-(thio)carboxamides.

✍ Y. EL-AHMAD; J.-D. BRION; P. REYNAUD; D. AVERBECK; S. AVERBECK 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 1 views

Synthesis and Photobiological Activity of N-Substituted 2-Oxo-2H-1benzopyran-3-(thio)carboxamides. -Piperidine-catalyzed condensation of benzaldehydes (I) with the malonic derivatives (II) gives a variety of polyfunctional coumarins ( III) (12 examples). They react readily with methyl iodide to the

ChemInform Abstract: Synthesis and Antii

ChemInform Abstract: Synthesis and Antiinflammatory Activity of N-Substituted 2-Oxo-2H-1-benzopyran-3-carboxamides and Their 2-Iminoanalogues.

✍ Igor E. Bylov; Maksym V. Vasylyev; Yaroslav V. Bilokin 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

Synthesis and pharmacological activity o

Synthesis and pharmacological activity of 2-oxo-(2H) 1-benzopyran-3-carboxamide derivatives

✍ L Bonsignore; G Loy; D Secci; A Calignano 📂 Article 📅 1993 🏛 Elsevier Science 🌐 French ⚖ 273 KB

Novel reactions of carbon suboxide. IV.

Novel reactions of carbon suboxide. IV. Synthesis of some N-Hydroxy-2-oxo-2H-1-benzopyran-3-carboxamides

✍ Leonardo Bonsignore; Giuseppe Loy; Mario Secci; Salvatore Cabiddu 📂 Article 📅 1983 🏛 Elsevier Science 🌐 French ⚖ 170 KB